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Libraries

Install @solana/web3.js (v1) for transaction handling and @solana/spl-token for SPL token operations: 
npm install @solana/web3.js@1 @solana/spl-token bs58
This documentation uses @solana/web3.js v1. Version 2 has a different API for transaction handling.

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RPC Connection

import { Connection } from '@solana/web3.js';

const connection = new Connection('https://api.mainnet-beta.solana.com');
Solana provides a default RPC endpoint, but as your application grows, use a dedicated provider like Helius or Triton.

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Development Wallet

Never hardcode private keys in source code. Use environment variables or the Solana CLI keyfile.
import { Keypair } from '@solana/web3.js';
import bs58 from 'bs58';
import 'dotenv/config';

const wallet = Keypair.fromSecretKey(bs58.decode(process.env.PRIVATE_KEY));